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Figures 27 A & B indicate that those analogs that were previously found to block HGF dimerization were effective inhibitor of HGF/Met mediated cell scattering in MDCK cells, while those analogs with poor affinity for HGF were ineffective

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Furthermore, incomplete MOMP driven by mitochondrial adaptation and sublethal cytochrome c release has also been linked to the generation of BH3-mimetic drug-tolerant persister cells 76

Reconstitution volume, vial concentration and injection frequency all interact with the intended mg/kg figure, and small arithmetic errors compound across a study arm

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